Multiple sclerosis

• MacDonald criteria
• Dissemination in space: T2 hyperintense lesions ≥ 3mm in at least two of the classically affected areas
  • Periventricular white matter
  • Spinal cord
  • Infratentorial brain
  • Juxtacortical white matter
  • Cerebral cortex (an addition of recent revision)
• Dissemination in time
  • Presence of both gadolinium-enhancing and non-enhancing lesions on a single study
  • Presence of new lesions demonstrating hyperintensity on T2
  • Gadolinium enhancement on subsequent studies